The rising tide of data being generated by high-throughput approaches to drug screening is slowly bringing about a chemical revolution. Cheminformatics thus is becoming a big business. Just as the genomics boom created a need for bioinformaticians, an explosion in the amount of data generated by combinatorial chemistry and other high-throughput approaches to drug screening and drug design is creating a demand for chemoinformaticians. The demand for cheminformatics expertise has come primarily from the pharmaceutical industries and biotechnology industries. Chemical database creation and searching, and high throughput technologies, have become increasingly important to the chemistry based industries as well. Their jobs can range from the management of a database structures and biological data, to work involving combinatorial chemistry.